Capreomycin Powder for Inhalation in Guinea Pigs
نویسندگان
چکیده
28 Anthony J. Hickey 29 University of North Carolina at Chapel Hill, 1310 Kerr Hall, CB #7360, Chapel Hill, NC 3
منابع مشابه
Inhaled large porous particles of capreomycin for treatment of tuberculosis in a guinea pig model.
Capreomycin is used for the treatment of multidrug-resistant tuberculosis (MDR-TB), but it is limited therapeutically by its severe side effects. The objectives of the present studies were (i) to design low-density porous capreomycin sulfate particles for efficient pulmonary delivery to improve local and systemic drug bioavailability and capacity to reduce the bacillary load in the lungs in a m...
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متن کاملPhase I, single-dose, dose-escalating study of inhaled dry powder capreomycin: a new approach to therapy of drug-resistant tuberculosis.
Multidrug-resistant tuberculosis (MDR-TB) threatens global TB control. The lengthy treatment includes one of the injectable drugs kanamycin, amikacin, and capreomycin, usually for the first 6 months. These drugs have potentially serious toxicities, and when given as intramuscular injections, dosing can be painful. Advances in particulate drug delivery have led to the formulation of capreomycin ...
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